Radioresistance mechanisms of mammary tumor initiating cells: Unreliable biological conclusions based on limiting dilution assays
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منابع مشابه
Radioresistance mechanisms of mammary tumor initiating cells: unreliable biological conclusions based on limiting dilution assays.
The recent study of tumor initiating cells (TICs) in a p53 null mammary tumor model by Zhang et al. (1) emphasizes that the selective activation of the Akt and canonical Wnt/β-catenin signaling pathways within the tumorigenic TICs plays a critical role in radiation resistance of TICs. Limiting dilution experiments are used to estimate and to compare TIC frequencies in their protocols. As such, ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1002520107